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park
CTS038

Neurodegeneración. Mecanismos moleculares y modos de protección (GRUPO PARK)

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Líneas de investigación

Aproximaciones proteómicas, genómicas, transcriptómicas y metabolómicas.
Autofagia.
Búsqueda de agentes neuroprotectores (especialmente basados en productos de interés regional).
Búsqueda de agentes neuroprotectores a partir de sustancias de origen natural
Búsqueda de biomarcadores diagnóstico y pronóstico.
Efecto de plaguicidas.
Efecto mutaciones en genes relacionados con la enfermedad de Parkinson.
Etiología molecular del Parkinson.
Etiología y tratamiento de enfermedades neuromusculares
Evaluación del papel funcional de algunos de los principales polimorfismos de los denominados genes PARK asociados con un mayor riesgo de padecer la enfermedad de Parkinson (PINK1, DJ1 o LRRK2) y su relación con la desregulación del proceso de autofagia

Proyectos de investigación

ESTUDIO DE SOSPECHA DE ENFERMEDAD DE PARKINSON EN UN PACIENTE (SECUENCIACIÓN PARA K2 Y PARKG) EXP. 16/3846.
CONCESIÓN DE SUBVENCIONES PARA LA CONTRATACIÓN LABORAL DE DOCTORES POR CENTROS DE INVESTIGACIÓN Y DESARROLLO
FINANCIACIÓN ADICIONAL ASOCIADA A LA SUBVENCIÓN DE LA AYUDA RYC-2016-20883. ANUALIDAD 2018.
PS-ESTUDIO DE SOSPECHA DIAGNÓSTICA DE ENFERMEDAD DE ALZHEIMER EN UN PACIENTE (SECUENCIACIÓN PSEN1, EXONES 4 AL 8, APP, EXONES 16 Y 17 GENOTIPO ApoE.
SUBVENCIÓN A FAVOR DE LA UEX PARA LA REALIZACIÓN DE LAS ACTUACIONES "ACONDICIONAMIENTO ESPACIO PARA INVESTIGACIÓN Y MOBILIARIO. 2018"
FOMENTO DE LA CONTRATACIÓN DE PERSONAL DE APOYO A LA INVESTIGACIÓN. DECRETO 213/2017.
NEURODEGENERACIÓN. MECANISMOS MOLECULARES Y MODOS DE PROTECCIÓN. PARK
PRODUCTOS NATURALES CON POTENCIAL ANTI-ENVEJECIMIENTO: IDENTIFICACIÓN DE DIANAS Y MECANISMOS MOLECULARES
ROL DEL SISTEMA AUTOFÁGICO-LISOSOMAL EN LA NEUROPROTECCIÓN MEDIADA POR LA FRACCIÓN LIPÍDICA DE LA JALEA REAL EN MODELOS DE LA ENFERMEDAD DE PARKINSON
DISEÑO DE PRIMERS ESPECÍFICOS DE ESPECIE MEDIANTE PCR CUANTITATIVA
AYUDA DE INVESTIGACIÓN DENTRO DEL PROGRAMA OPORTUNIDAD AL TALENTO
CONVENIO - ESTUDIO GENÉTICO DE LA POBLACIÓN DE DESMÁN IBÉRICO (Galempys pyrenoicus) EN EXTREMADURA 2020-2021
ANÁLISIS DE LA FERTILIDAD EN GANADO AUTÓCTONO MEDIANTE PROCEDIMIENTOS GENÉTICOS
IDENTIFICACIÓN DE AGENTES NEUROPROTECTORES EN JALEA REAL
BIOMARCADORES PRONÓSTICOS GENÉTICOS E INMUNOLÓGICOS EN LA INFECCIÓN POR LA COVID-19
Proyecto Intramural A CIBERned drug discovery network to test Calcium modulators as treatment for ALS
OPE-EXTREMADURA. ACELERACIÓN DE GRUPOS DE INVESTIGACIÓN CON MAYORES CAPACIDADES PARA HORIZONTE EUROPA EN LA REGIÓN DE EXTREMADURA.
CONCESIÓN DE SUBVENCIÓN PARA LA CONTRATACIÓN DE DOCTORES POR CENTROS DE INVESTIGACIÓN Y DESARROLLO. JUAN DE LA CIERVA. PATRICIA GÓMEZ SUAGA.
ESTANCIAS BREVES EN OTROS CENTROS ESPAÑOLESY EXTRANJEROS Y PARA TRASLADOS TEMPORALES A CENTROS EXTRANJEROS A BENEFICIARIOS DEL SUBPROGRAMA DE FORMACIÓN DEL PROFESORADO UNIVERSITARIO
IDENTIFICACIÓN DE DIANAS TERAPÉUTICAS DE COMPUESTOS BIOACTIVOS PROCEDENTES DE CASCABULLO DE BELLOTA EN MODELOS DE NEURODEGENERACIÓN
Centro de investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)
AYUDA AL GRUPO DE INVESTIGACIÓN DENOMINADO "NEURODEGENERACIÓN, MECANISMOS MOLECULARES Y MODOS DE PROTECCIÓN"
ESTUDIO DEL ESTADO DE CONSERVACIÓN DEL DESMÁN IBÉRICO (GALEMYS PYRENAICUS), LOBO IBÉRICO (CANIS LUPUS SIGNATUS), TOPILLO NIVAL (CHIONOMYS NIVALIS) Y TOPILLO DE CABRERA (MICROTUS CABRERAE) MEDIANTE EL USO DE HERRAMIENTAS DE GENÉTICA MOLECULAR COMO BASE DE LA GESTIÓN PARA LA CONSERVACIÓN DE ESTAS ESPECIES Y SU HÁBITAT
MECANISMOS QUE MEDIAN EL PAPEL NEUROPROTECTOR DE LA FRACCIÓN LIPÍDICA DE LA JALEA REAL DE ABEJA

Publicaciones

Semiological value of rhythmic ictal non-clonic hand (RINCH) motions in epileptic seizures.
STIM1-containing contact sites promote direct calcium flux from the endoplasmic reticulum to mitochondria.
Identification of ACBP as a potential target in ciliopathic obesity through multi-omics network analysis.
Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice.
Epigenetic regulation of HOXA2 expression affects tumor progression and predicts breast cancer patient survival.
Perceptions of key informant neurologists before implementing anti-amyloid drugs in the Spanish departments of neurology.
Convergence of Neuroinflammation, Microbiota, and Parkinson's Disease: Therapeutic Insights and Prospects.
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells.
ER-mitochondria signaling in Parkinson´s disease.
Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis.
Critical points in the experience of spouse caregivers of patients who have suffered a stroke. A phenomenological interpretive study.
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells.
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Statins do not increase Markers of Cerebral Angiopathies in patients with Cardioembolic Stroke.
Vascular Risk Factors and Lesions of Vascular Nature in Magnetic Resonance as Predictors of Progression to Dementia in Patients with Mild Cognitive Impairment.
[Evaluation of quality of life, social stigma and treatment adherence in patients with epilepsy in the Caceres Healthcare Area: a cross-sectional study].
Acetylome in Human Fibroblasts From Parkinson´s Disease Patients.
LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer´s disease brains.
Natural Products in the Promotion of Healthspan and Longevity.
The paradigm of protein acetylation in Parkinson´s disease.
Toxicity of Necrostatin-1 in Parkinson´s Disease Models.
Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson´s Disease Patients.
Disruption of endoplasmic reticulum- mitochondria tethering proteins in post-mortem Alzheimer´s disease brain.
Cholesterol and multilamellar bodies: Lysosomal dysfunction in GBA-Parkinson disease.
Depressed Mood after Stroke: Predictive Factors at Six Months Follow-Up.
Autophagy modulation in animal models of corneal diseases: a systematic review.
Will neurological care change over the next 5 years due to the COVID-19 pandemic? Key informant consensus survey.
COVID-19 and concomitant neurological infections.
Animal models used to study direct peripheral nerve repair: a systematic review.
Metabolic alterations in plasma from patients with familial and idiopathic Parkinson´s disease.
A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery.
Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
The VAPB-PTPIP51 endoplasmic reticulum- mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity.
MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation.
Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack.
The dual role of necrostatin-1 in Parkinson´s disease models.
Does the Global Postural Re-Education Affect the Psychological and Postural Aspects of Alzheimer Disease Patients? A Six Months Quasi Experimental Study.
Stroke care during the COVID-19 outbreak in Spain: the experience of Spanish stroke units.
The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.
Delay of EGF-Stimulated EGFR Degradation in Myotonic Dystrophy Type 1 (DM1).
Fibrilación auricular y deterioro cognitivo: una revisión narrativa [Atrial fibrillation and cognitive impairment: a narrative review].
Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson´s Disease: The Implication of Lipid Droplets and Lipophagy.
Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles.
In vitro and in vivo models to study the biological and pharmacological properties of queen bee acid (QBA, 10-hydroxy-2-decenoic acid): A systematic review.
Biological effects of olive oil phenolic compounds on mitochondria.
The cognitive and psychiatric subacute impairment in severe Covid-19.
Role of Inflammatory Cytokines in the Conversion of Mild Cognitive Impairment to Dementia: A Prospective Study.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Links Between Paraquat and Parkinson’s Disease. In: Kostrzewa, R.M.
Neuroprotective properties of queen bee acid by autophagy induction.
Comparative Genetic Analysis of the Promoters of the ATG16L1 and ATG5 Genes Associated with Sporadic Parkinson's Disease
Nurses' Perceptions Regarding Their Professional Commitment and Development during the COVID-19 Pandemic.
Poor communication between ER and mitochondria: a signature of ALS/FTD?
Immunological aspects of central neurodegeneration.
Mitochondrial Dysfunction in Repeat Expansion Diseases.
Role of TFEB in Huntington's Disease
Heat shock and thermotolerance in Caenorhabditis elegans: An overview of laboratory techniques.
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects.
Vitamin D Receptor Polymorphisms in a Spanish Cohort of Parkinson's Disease Patients.
Lysosomal Dysfunction: Connecting the Dots in the Landscape of Human Diseases.
Insight into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis.
Links Between Paraquat and Parkinson’s Disease
Nurses' Perceptions of Ethical Conflicts When Caring for Patients with COVID-19
Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration
Changes in Liver Lipidomic Profile in G2019S- LRRK2 Mouse Model of Parkinson's Disease
Detection of rare genetic variations in the promoter regions of the ATG16L gene in Parkinson's patients
Multiple intracerebral haemorrhages and ubiquitous brain microbleeds in a patient with Down syndrome: cerebral amyloid angiopathy.
Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation.
The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases.