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BBB003

Biología Molecular del Cáncer

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Líneas de investigación

Angiogénesis.
Células madre tumorales.
Crecimiento tumoral.
Genómica, transcriptómica, metabolómica.
Interacción tumor-estroma.
Marcadores diagnósticos y dianas terapéuticas en hepatocarcinoma, melanoma, glioblastoma.
Mecanismos moleculares de diferenciación y pluripotencia
Metástasis.
Mutaciones y genética tumoral.
Neurotoxicidad de dioxinas

Proyectos de investigación

FIS AND KIDS. AYUDA PARA EL FOMENTO DE LA CULTURA CIENTÍFICA, TECNOLÓGICA Y DE LA INNOVACIÓN
LA VENTANA DE LA CIENCIA
ESTUDIOS MOLECULARES EN LEUCEMIAS INFANTILES Y HEPATOCARCINOMA USANDO CÉLULAS MADRES PLURIPOTENTES INDUCIDAS (IPSC)
BÚSQUEDA DE NUEVOS ANTIFÚNGICOS MEDIANTE LA INHIBICIÓN DE LA RUTA DE SEÑALIZACIÓN DE LA NDR QUINASA CBK1 EN CÁNDIDA ALBICANS
IMPLICACIÓN DE LAS CÉLULAS ESTRELLADAS DEL PÁNCREAS EN LAS PATOLOGÍAS QUE AFECTAN A LA GLÁNDULA. EFECTOS DE LA MELATONINA
LABORATORIO DE COMPORTAMIENTO Y ECOFISIOLOGÍA EN FAUNA SILVESTRE (PRÉSTAMO)
LABORATORIO DE BIOQUÍMICA CELULAR Y ENDOCRINOLOGÍA MOLECULAR
REGULACIÓN DE LA POLIPLOIDIA HEPÁTICA, LA REPROGRAMACIÓN Y EL CARCINOMA HEPTATOCELULAR POR LA RUTA DEL RECEPTOR DE DIOXINA
LABORATORIO DE COMPORTAMIENTO Y ECOFISIOLOGÍA EN FAUNA SILVESTRE
GRUPO BIOLOGÍA MOLECULAR DEL CÁNCER (BBB - 003 FINAL)
PREMIO ACCIÓN SOCIAL 2017 - ESTUDIOS MOLECULARES EN LEUCEMIAS INFANTILES Y HEPATOCARCINOMA USANDO CÉLULAS MADRES PLURIPOTENTES INDUCIDAS (IPSC), REGISTRADO CON EL NÚMERO 057
SISTEMA DE ANÁLISIS DE MICROSCOPÍA CONFOCAL DE ALTA RESOLUCIÓN
AYUDAS FORMACIÓN PERSONAL INVESTIGADOR 2018 - PRE2018-085587 - ORDIALES TALAVERO,ANA
AYUDAS FORMACIÓN PERSONAL INVESTIGADOR 2018 - PRE2018-085587 - ORDIALES TALAVERO,ANA. DOTACIÓN ADICIONAL INVESTIGADOR.
BIOMARCADORES PRONÓSTICOS E INMUNOLÓGICOS EN LA INFECCIÓN POR LA COVID-19
OPE-EXTREMADURA. ACELERACIÓN DE GRUPOS DE INTERVENCIÓN CON MAYORES CAPACIDADES PARA HORIZONTE EUROPA EN LA REGIÓN DE EXTREMADURA
NUEVAS INSTALACIONES SPF Y ADECUACIÓN DE LA NORMATIVA VIGENTE DEL ANIMALARIO DEL CAMPUS DE BADAJOZ EN LA UNIVERSIDAD DE EXTREMADURA
SISTEMA DE MICROSPCOPÍA AVANZADA PARA ÓRGANOS, EMBRIONES, CULTIVOS CELULARES Y ALTA RESOLUCIÓN
AYUDA AL GRUPO DE INVESTIGACIÓN DENOMINADO "BIOLOGÍA MOLECUALR DEL CÁNCER"
MECANISMOS QUE REGULAN LA INTERACCIÓN SENESCENCIA-REPROGRAMACIÓN EN CARCINOMA HEPATOCELULAR: IMPLICACIÓN EN REGENERACIÓN HEPÁTICA
REGULACIÓN DE LA REPROGRAMACIÓN Y LA SENESCENCIA EN EL CARCINOMA HEPATOCELULAR POR POR EL RECEPTOR Ahn: IMPLICACIONES CLÍNICAS

Publicaciones

Futility in adenosquamous pancreatic cancer.
ASO Visual Abstract: Adenosquamous Carcinoma of the Pancreas: Outcomes of a Multicenter European Study (ADESQUPAN Project).
Consensus statement on obesity management in liver transplantation candidates.
Adenosquamous Carcinoma of the Pancreas: Outcomes of a Multicenter European Study (ADESQUPAN Project).
Excluding Ascites From the GEMA-Na Score Does Not Impact Outcome Predictions in Liver Transplant Candidates.
Surgical treatment of liver metastasis from pancreatic cancer
Blumgart Anastomosis Versus Invaginating Pancreato-gastrostomy For Reconstruction After Pancreatoduodenectomy: A Randomized Controlled Trial
Assessing the Potential Difficulty of Left Pancreatectomy: International Modified Delphi Consensus.
Effect of Volume on Postoperative Outcomes After Left Pancreatectomy: A Multicenter Prospective Snapshot Study (SPANDISPAN Project)
Anastomosis Versus Invaginating Pancreato-gastrostomy For Reconstruction After Pancreatoduodenectomy: A Randomized Controlled Trial.
Which risk factors are related to failure to rescue in left pancreatectomy? Mixed cohort study (ERPANDIS and SPANDISPAN projects).
Which risk factors are related to failure to rescue in left pancreatectomy? Mixed cohort study (ERPANDIS and SPANDISPAN projects).
Involvement of β-catenin expression in hepatocellular carcinoma prognosis in a cohort of patients undergoing curative treatment
Editorial: Senescence and reprogramming: hallmarks in aging and disease.
Assessing the Potential Difficulty of Left Pancreatectomy: International Modified Delphi Consensus.
Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue Sarcoma: Updated Review and Clinical Recommendations.
Intraoperative liquid biopsy as a tool for detecting R1 resection during pancreatoduodenectomy in patients with pancreatic carcinoma: the CETUPANC trial (part II)
Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling.
A Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism.
Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish.
Melatonin induces reactive oxygen species generation and changes in glutathione levels and reduces viability in human pancreatic stellate cells.
The UK DCD Risk Score: Still no consensus on futility in DCD liver transplantation.
Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation.
The melatonin receptor antagonist luzindole induces Ca2+ mobilization, reactive oxygen species generation and impairs trypsin secretion in mouse pancreatic acinar cells.
Pattern of Relapse in Hepatic Hydatidosis: Analysis of 238 Cases in a Single Hospital.
The Impact of Culturing the Organ Preservation Fluid on Solid Organ Transplantation: A Prospective Multicenter Cohort Study
A survey of Heads of Surgery and Residents on accessibility and employment in liver transplant teams in Spain
Actualización en el manejo de sarcomas retroperitoneales y pévicos; el papel de la cirugía compartimental.
Postoperative bleeding and biliary leak after liver resection: A cohort study between two different fibrin sealant patches.
Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia. Biol Cell.112(10):280-299,
The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value.
Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells.
Side-to-side duodenojejunostomy after resection of third and fourth duodenal portions with pancreatic preservation
Distal pancreatectomy with multivisceral resection: A retrospective multicenter study - Case series.
Lack of the aryl hydrocarbon receptor accelerates aging in mice.
Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.
Reply to: "Normothermic regional perfusion - What is the benefit?".
Melatonin Induces Apoptosis and Modulates Cyclin Expression and MAPK Phosphorylation in Pancreatic Stellate Cells Subjected to Hypoxia.
Perioperative chemotherapy versus surgery alone for resectable colorectal liver metastases: an international multicentre propensity score matched analysis on long-term outcomes according to established prognostic risk scores.
Preoperative hepatic artery embolization before distal pancreatectomy plus celiac axis resection does not improve surgical results: A Spanish multicentre study.
Pancreatic resection for metastatic renal cell carcinoma. A systematic review.
Alu retrotransposons modulate Nanog expression through dynamic changes in regional chromatin.
The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development
Melatonin modulates proliferation of pancreatic stellate cells through caspase-3 activation and changes in cyclin A and D expression.
Loss of Aryl Hydrocarbon Receptor Favors K-RasG12D-Driven Non-Small Cell Lung Cancer
Exploring Health Science Students´ Notions on Organ Donation and Transplantation: A Multicenter Study.
Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID)
Confident Perception of Primary Care Physicians Correlates to the Attitude Toward Donation and Organ Transplantation: A Multicenter Study of Medical And Nursing Spanish Students.
Durvalumab as a Successful Downstaging Therapy for Liver Transplantation in Hepatocellular Carcinoma
Organ Donation Related With Attitude Toward the Law of Presumed Consent: Spanish University Medical and Nursing Students Study.
Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia
Changes in Humoral Immune Response after SARS-CoV-2 Infection in Liver Transplant Recipients Compared to Immunocompetent Patients
Prospective Study Correlating External Biliary Stenting and Pancreatic Fistula Following Pancreaticoduodenectomy
Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients.
Prospective Study Correlating External Biliary Stenting and Pancreatic Fistula Following Pancreaticoduodenectomy.
Implementation of a regional reference center in pancreatic surgery. Experience after 631 procedures.
Jaundice as a clinical presentation in liver hydatidosis increases the risk of postoperative biliary fistula.
Liver regeneration after partial hepatectomy is improved in the absence of aryl hydrocarbon receptor.
Applicability and reproducibility of the validated intraoperative bleeding severity scale (VIBe scale) in liver surgery: A multicenter study.
Adenoma tubulopapilar quístico con diferenciación apocrina: descripción de un caso con mutación de BRAF V600E y revisión de la literatura [Cystic tubulopapillary adenoma with apocrine differentiation and BRAF V600E mutation. A case report and review of the literature].
Adenosquamous cancer of the pancreas: A multicenter retrospective study.
Decreased Long-Term Severe Acute Respiratory Syndrome Coronavirus 2-Specific Humoral Immunity in Liver Transplantation Recipients 12 Months After Coronavirus Disease 2019.
Textbook Outcome in Distal Pancreatectomy.
Liver resection in elderly patients with extensive CRLM: Are we offering an adequate treatment? A propensity score matched analysis.
Aryl hydrocarbon receptor controls skin homeostasis, regeneration, and hair follicle cycling by adjusting epidermalstem cell function
Reaching a consensus on the definition of "difficult" cholecystectomy among Spanish experts. A Delphi project. A qualitative study.
Prognostic value of pre-operative systemic immune-inflammation index and platelet to lymphocyte ratio in peritoneal carcinomatosis of ovarian origin.
ASO Visual Abstract: Long-Term Outcomes of Perioperative versus Neoadjuvant Chemotherapy for Resectable Colorectal Liver Metastases-An International Multicenter Propensity-Score Matched Analysis with Stratification by Contemporary Risk Scoring.
Surgical treatment of liver hydatid cyst in elderly patients: A propensity score-matching retrospective cohort study.
Pancreatic mucinous cystic neoplasms located in the distal pancreas: a multicenter study.
Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.
From Nucleus to Organs: Insights of Aryl Hydrocarbon Receptor Molecular Mechanisms.
Aryl Hydrocarbon Receptor: From Homeostasis to Tumor Progression.
Dynamic BOLD MRI Shows Greater Foot Ischemia and Blunted Reperfusion Following Cuff-Occlusion Challenge in Diabetic Patients with Foot Ulcers.
Influence of the tumor site and histopathology after resection for non-colorectal non-neuroendocrine liver metastases. A single center experience.
Elevated Foot Diffusion and Resting Perfusion in Patients with Diabetic Foot Ulcer: A Pilot and Feasibility Study.
Resection of isolated pancreatic metastases from pulmonary neoplasia: a systematic review.
Textbook outcome in the surgical treatment of liver hydatid cyst.
Identification of environmental factors that promote intestinal inflammation.
Long-term outcomes after breast cancer liver metastasis surgery: A European, retrospective, snapshot study (LIBREAST STUDY)
Textbook outcomes in the liver-first approach for colorectal liver metastases: prospective multicentre analysis.
Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID).
Benchmark Outcomes for Distal Pancreatectomy: A Multicenter Prospective Snapshot Study from the Spanish Distal Pancreatectomy Project (SPANDISPAN).
GEMA-Na and MELD 3.0 severity scores to address sex disparities for accessing liver transplantation: a nationwide retrospective cohort study.
Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project).
Short- and long-term outcomes after distal pancreatectomy with radiologic infiltration of splenic vessels for pancreatic ductal adenocarcinoma
Textbook outcome in distal pancreatectomy: A multicenter study.
Aparicio-López D, Asencio-Pascual JM, Blanco-Fernández G, Cugat-Andorrá E, Gómez-Bravo MÁ, López-Ben S, Martín-Pérez E, Sabater L, Ramia JM, Serradilla- Martín M.
Serradilla Martín M, Villodre Tudela C, Rotellar F, Blanco Fernández G, Ramia JM; miembros del Grupo de Trabajo ERPANDIS.
Sanmarco LM, Rone JM, Polonio CM, Fernandez Lahore G, Giovannoni F, Ferrara K, Gutierrez-Vazquez C, Li N, Sokolovska A, Plasencia A, Faust Akl C, Nanda P, Heck ES, Li Z, Lee HG, Chao CC, Rejano-Gordillo CM, Fonseca-Castro PH, Illouz T, Linnerbauer M, Kenison JE, Barilla RM, Farrenkopf D, Stevens NA, Piester G, Chung EN, Dailey L, Kuchroo VK, Hava D, Wheeler MA, Clish C, Nowarski R, Balsa E, Lora JM, Quintana FJ.
Corrigendum to 'Regulation of cell death receptor S-nitrosylation and apoptotic signaling by Sorafenib in hepatoblastoma cells
Involvement of β-catenin expression in hepatocellular carcinoma prognosis in a cohort of patients undergoing curative treatment
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial